The Open Pain Journal

2013, 6 : 119-126
Published online 2013 March 08. DOI: 10.2174/1876386301306010119
Publisher ID: TOPAINJ-6-119

RESEARCH ARTICLE
 Targeting TRPV3 for the Development of Novel Analgesics

Susan M. Huang1 and Man-Kyo Chung, *,1
1 Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
2 Department of Neural and Pain Sciences, School of Dentistry, Program in Neuroscience, University of Maryland, 650 W. Baltimore Street, Baltimore, MD 21201, USA

* Address correspondence to this author at the Department of Neural and Pain Sciences, School of Dentistry, Program in Neuroscience, University of Maryland, 650 W. Baltimore Street, Baltimore, MD 21201, USA; Tel: 410-706-4452; Fax: 410-706-0865; E-mail: mchung@umaryland.edu

ABSTRACT

Decades of characterization of the transient receptor potential vanilloid subtype 1 (TRPV1) have led to the realization of its central role in thermosensation and pain perception. A large number of pharmaceutical companies have had interest in developing TPRV1 antagonists for the treatment of pain. The subsequent discovery of multiple other members of this TRPV family has not gone unnoticed. TRPV3 exhibits approximately 40% homology to TRPV1, and has common as well as distinct features from TRPV1 in channel physiology, expression and function. Here we review the current understanding of TRPV3 channel biology, activation, sensitization and the consequences of TRPV3 manipulation for thermosensation and nociception, as well as additional considerations regarding the expression of TRPV3 in the skin. We weigh in on the available evidence in the context of potential development of TRPV3 modulating agents as analgesics.

Keywords:

TRPV3, Novel Analgesics, Thermosensation, Pain Perception.