The Open Pain Journal

2016, 9 : 26-37
Published online 2016 September 30. DOI: 10.2174/1876386301609010026
Publisher ID: TOPAINJ-9-26

RESEARCH ARTICLE
 The Complement System in Neuropathic and Postoperative Pain

David C. Fritzinger and Daniel E. Benjamin, *

Address correspondence to this author at Cascade Biotechnology, 9 Deer Park Drive, Monmouth Junction, New Jersey, USA; Tel/Fax: 9087830338; E-mail DB@CENOXsys.com

ABSTRACT

Certain types of pain are major unmet medical needs that affect more than 8 percent of the population. Neuropathic pain can be caused by many pathogenic processes including injury, autoimmune disease, neurological disease, endocrine dysfunction, infection, toxin exposure, and substance abuse and is frequently resistant to available pain therapies. The same can be said of post-surgical pain, which can arise from uncontrolled inflammation around the wound site. The complement system is part of the innate immune system and can both initiate and sustain acute and chronic inflammatory pain. Here we review the complement system and original investigations that identify potential drug targets within this system. Drugs that act to inhibit the complement system could fill major gaps in our current standard of care for neuropathic pain states.

Keywords:

Complement, Complement inhibition, Neuropathic pain, Post-operative pain.