The Open Pathology Journal

2010, 4 : 67-79
Published online 2010 April 14. DOI: 0.2174/1874375701004010067
Publisher ID: TOPATJ-4-67

Molecular Markers in Diagnostic Paediatric Bone Lesions

Brendan C. Dickson , Catherine T-S. Chung and Adrienne M. Flanagan
Institute of Orthopaedics and Musculoskeletal Science, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK;

ABSTRACT

Molecular pathology has become an essential adjunct in the realm of diagnostic histopathology. While gains in this field have been enjoyed in many areas, their impact has arguably been greatest felt in bone and soft tissue pathology. The purpose of this paper is to highlight the emerging role of molecular techniques in the context of paediatric bone pathology, discussing select syndromic and neoplastic processes affecting this demographic. To this end, we review the salient molecular advances bridging both clinical research and clinical practice.

Keywords:

Bone tumours, bone lesions, paediatric, molecular markers, diagnosis.