Prostate Cancer Lymph Node Metastasis

ABSTRACT

Prostate cancer is the most commonly diagnosed malignancy and the leading cause of cancer-related mortality among men in Australia and the USA. A key turning point in the course of cancer progression is the development of metastatic potential as most prostate cancer related deaths are not due to the primary tumour, but rather to metastases. A better understanding of molecular mechanisms that underlie the process of prostate cancer metastasis to lymph nodes will most likely result in improved therapeutic options for patients and thus help reduce the burden of the disease. This review will focus on the current knowledge of molecular mechanisms that regulate the spread of prostate cancer to lymph nodes and potential new targets for therapy.