The Open Prostate Cancer Journal
2012, 5 : 15-19Published online 2012 July 11. DOI: 10.2174/1876822901205010015
Publisher ID: TOPCANJ-5-15
Impact of Percentage of Positive Biopsy Cores on Biochemical Outcome in Patients Treated With Low-Dose Rate (Iodine-125) Brachytherapy for Prostate Cancer
ABSTRACT
• To investigate the significance of the percentage of positive biopsy cores (PPBCs) in predicting the biochemical outcome in patients with clinically localised prostate cancer undergoing low-dose rate brachytherapy (LDRB).
• A total of 326 consecutive patients underwent LDRB between February 1997 and January 2007. The cohort consisted of 68.7%, 30.4% and 0.9% of low-, intermediate- and high-risk groups respectively as defined by the D'Amico classification. Patients were stratified according to PPBCs (<35%, 35-50%, >50%).
• Of the 326 men, 316 (97%) met the study criteria and were included in the analysis. The median follow-up was 66.3 (12.9-147.5) months. Thirty-eight men (12%) developed evidence of biochemical relapse as defined by the Phoenix definition at a median of 44.5 (4-133) months. The overall 5-year and 10-year biochemical relapse-free rate (BRFR) was 91.9% (95% CI 87.9% to 94.6%) and 76.9% (95% CI 66% to 84%) respectively.
• On univariate analysis, Gleason score (p=0.03), D'Amico risk groups (p=0.004) and PPBCs (p=0.001) were significant predictors of biochemical failure. In the multivariate model, the PPBCs (p=0.0006) and pretreatment PSA (p=0.004) were the only variables that predicted for biochemical failure. The 5-year biochemical relapse-free rate was 93.5%, 93.0% and 76.5% for the PPBCs <35%, 35%-50% and >50% respectively (p=0.001).
Conclusions:
• The PPBC is an important independent predictor of the 5-year biochemical relapse-free survival after LDRB. This finding suggests that patients with high volume tumour are at increased risk of biochemical failure with LDRB.