The Open Physical Chemistry Journal

2014, 6 : 1-7
Published online 2014 January 23. DOI: 10.2174/1874067701406010001
Publisher ID: TOPCJ-6-1

Effect of Dioxane on N-(4-hydroxy-6-methyl-1,3,5-triazin-2-yl)-N’- phenylthiocarbamide

D. T. Tayade , A. M. Kshirsagar and Y. Yang
Department of Chemistry, Alamuri Ratnamala Institute of Engineering and Technology, Sapgaon, Taluka-Shahapur, Dist.-Thane (M.S.), Mumbai University, (M.S.), India

ABSTRACT

In present times, the drugs containing S-triazino and thiocarbamido nucleus created their own identity and importance in medicinal, pharmaceutical and industrial fields due to their ability of curing wide range of diseases caused by various pathogens. These types of drugs showed remarkable and noticeable antibacterial, antifungal and antiviral activities. Hence, viscometric, refractrometric and interferometric measurements of recently synthesized compound have been investigated at 25°C in 60% dioxane-water system at various concentrations. The results obtained in these studies evidently explain polarizability, mutual compensation of dipoles and solute-solvent interactions. The values of acoustic parameters are useful for cross justification of solute-solvent interactions. These results are most indispensable for knowing the pharmacokinetics and pharmacodynamics of any drug. An absorption, transmission, metabolism and excretion of any drug depend on solute-solvent, solute-solute-solvent and solute-solvent-solvent interactions, taking all these things into consideration this research work was carried out.

Keywords:

Viscometric, refractrometry and interferometric measurements, pharmacokinetics and pharmacodynamics..