The Open Pediatric Medicine Journal

2020, 10 : 3-5
Published online 2020 June 16. DOI: 10.2174/1874309902010010003
Publisher ID: TOPEDJ-10-3

CASE REPORT
 Anaplastic Large Cell Lymphoma ALK-Negative: About a Rare Pediatric Case Report

Louachama Ouidad1, * , Elbaz Meriem2 and El Houdzi Jamila1

*Address correspondence to this author at the Department of Pediatric Hematology and oncology, University Hospital Mohammed VI, Marrakesh, , E-mail: louachamaouidad@gmail.com

ABSTRACT

Introduction:

Anaplastic Large Cell Lymphomas (ALCL) are rare in childhood but clinically aggressive. The contemporary World Health Organization (WHO) classification of hematologic malignancies recognizes two distinct subtypes of systemic ALCL: Anaplastic Lymphoma Kinase (ALK)-negative, and ALK-positive.

Case report:

We report a rare pediatric observation of cutaneous nodule revealing an Anaplastic Large Cell Lymphoma (ALCL) ALK - cutaneous, muscular and ganglionic. It was classified according to who classification, treated by polychemotherapy with good outcome.

Conclusion:

ALCL encompasses several distinct clinicopathologic entities with unique genomic under printing. This rare pediatric observation of ALCL presents a new discussion on a pathology still incompletely known.

Keywords:

Anaplastic large cell lymphoma, Negative ALK, Child, Polychemotherapy, Ultrasound, Hematologic malignancies.