The Management of Paediatric Crohn’s Disease: Addressing Unmet Needs

ABSTRACT

Abstract: Paediatric Crohn’s disease (CD) affects 5 in 100,000 children in the US and Europe and can result in growth retardation and delayed sexual development. Therefore, early diagnosis and treatment is critical, with the goal being maintenance of symptomatic remission and a change in disease course. Conventional treatment relies on aminosalicylate maintenance therapy with corticosteroids to control acute exacerbations and immunomodulators for steroid-resistant or frequently relapsing disease. Infliximab has demonstrated efficacy in moderately to severely active paediatric CD, with 88.4% patients in clinical response and 58.9% in clinical remission at week 10. Significant improvements in quality of life, height, reduction in corticosteroid use and mucosal healing were observed with infliximab. Traditional ‘step-up’ treatment strategy may be suboptimal because relapse and steroid dependency/resistance rates remain high. A ‘top down’ approach using biologic therapy earlier may suppress intestinal inflammation and promote prolonged and stable remission, but safety issues need to be considered.

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