The Open Pediatric Medicine Journal

2009, 3 : 31-32
Published online 2009 March 20. DOI: 10.2174/1874309900903010031
Publisher ID: TOPEDJ-3-31

Reversion to the Neurovilurent Genome Sequence of Polio Vaccine Virus Isolated from Community-Acquired Meningitis

Zenichiro Kato , Yasushi Shimada , Hiroaki Ishiko and Naomi Kondo
Department of Pediatrics, Graduate School of Medicine, Gifu University, Yanagido 1-1, Gifu 501- 1194, Japan.

ABSTRACT

Neurologic complication associated with the use of live attenuated oral poliomyelitis vaccine is uncommon, but vaccine-associated paralytic poliomyelitis in recipients or contacts has sometimes been reported. We report here a community- acquired aseptic meningitis case and the genetic investigation of the isolated poliovirus type 2. The results of the genetic analysis indicate that the mechanism of this meningitis could be the result of the reversion of the virus during replication in the other vaccine recipients, suggesting a quest for revising the current vaccination program.

Keywords:

Poliovirus, vaccine, meningitis.