The Open Pacing, Electrophysiology & Therapy Journal

2010, 3 : 21-27
Published online 2010 November 11. DOI: 10.2174/1876536X01003010021
Publisher ID: TOPETJ-3-21

Simulation of T-Wave Alternans and its Relation to the Duration of Ventricular Action Potentials Disturbance

Dariusz Janusek , Michal Kania , Roman Kepski and Roman Maniewski
ul. Ks. Trojdena 4, 02-109 Warsaw, Poland

ABSTRACT

The aim of the study was to simulate T-wave alternans (TWA) magnitude distribution maps on the body surface employing ECGSIM program and then to compare obtained results with data measured from patients. The toolbox for ECGSIM program was developed for TWA simulation. Graphical representation of spatial distribution of TWA magnitude was implemented. Body surface maps of TWA were simulated for different locations of the disturbances on the heart. Simulated data were compared with recordings from patients and similarities were found. Preliminary study shows that ECGSIM program can be used for approximate location of action potential disturbances in the heart cells.

Keywords:

T-wave alternans, T-wave morphology, electrocardiogram simulation, action potential duration.