Protective Effects of Mangifera indica L. Extract Against Lipofundininduced Oxidative Stress in Rats

ABSTRACT

Lipofundin is a lipid rich emulsion used in parenteral nutrition. It is known that Lipofundin induces an oxidative stress state characterized by an increase of lipid peroxidation and a dramatic depletion of antioxidants. The aim of the present study was to evaluate the effects of an aqueous extract of Mangifera indica L., on Lipofundin-induced oxidative stress. Male Sprague Dawley rats were treated orally with 200 mg/kg of Vimang®, followed by an intravenous dose of 2 mL/kg Lipofundin, daily, for 8 days. Selected oxidative stress biomarkers were then measured spectrophotometrically. The results showed that Vimang® produced significant (p<0.05) reduction of malondialdehyde, total hydroperoxides and advanced oxidation protein products, while the activities of superoxide dismutase and catalase were positively modulated. A significant (p<0.05) reduction of peroxidation potential and a preservation of glutathione and total antioxidant status was also observed. Our data demonstrated that Vimang® protects against Lipofundin-induced oxidative stress, which is an important finding that further reinforces the antioxidant properties of this natural product.