The Open Physiology Journal

2008, 1 : 28-33
Published online 2008 August 08. DOI: 10.2174/1874360900901010028
Publisher ID: TOPHYJ-1-28

Androgen Receptor Expression and Function in Osteoclasts

R.A. Davey , A.J. Notini , W.S.M. Chiu , J. Hodge , G. Nicholson , J.D. Zajac and A.G. Turner
Department of Medicine, Austin Health, University of Melbourne, Level 7, Lance Townsend Building, Studley Road, Heidelberg, Victoria, 3084,Australia.

ABSTRACT

We assessed androgen receptor (AR) expression in osteoclasts in vitro and in situ. Rat multinucleated osteoclasts expressed detectable AR protein in situ, and AR mRNA was detected in mouse and human derived osteoclast-like cells in vitro. Dihydrotestosterone treatment did not affect human osteoclast-like cell formation or resorption in vitro.

Keywords:

Androgen receptor, osteoclasts, bone resorption.