The Open Psychiatry Journal

2008, 2 : 1-4
Published online 2008 January 29. DOI: 10.2174/1874354400802010001
Publisher ID: TOPJ-2-1

A Case of Schizophrenia with Chromosomal Microdeletion of 17p11.2 Containing a Myelin-Related Gene PMP22

Yuji Ozeki , Takeshi Mizuguchi , Naotsugu Hirabayashi , Masafumi Ogawa , Naomi Ohmura , Miyuki Moriuchi , Naoki Harada , Naomichi Matsumoto and Hiroshi Kunugi
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.

ABSTRACT

We report a patient with schizophrenia who had a chromosomal deletion of 17p11.2 containing a myelinrelated gene PMP22 by using comparative genomic hybridization (CGH) array and quantitative PCR. Since genetic linkage to 17p11, reduced expression of PMP22, and alterations in m

Keywords:

Schizophrenia, PMP22, 17p11.2..