The Open Conference Proceedings Journal

2011, 2 : 17-20
Published online 2011 April 27. DOI: 10.2174/2210289201102010017
Publisher ID: TOPROCJ-2-2-17

Enantioselective Extraction of Racemic Amlodipine Using Tartaric Acid Derivatives and β-Cyclodextrin Derivatives as Chiral Selectors

Hairul Nazirah Abdul Halim and Maizatul Akmam Ahmad
School of Bioprocess Engineering, Universiti Malaysia Perlis, Kompleks Pusat Pengajian Jejawi 3, 02600 Arau, Perlis, Malaysia.

ABSTRACT

The distribution behavior of amlodipine enantiomers in a two-phase system containing tartaric acid derivatives in organic phase and beta-cyclodextrin (β-CD) derivatives in aqueous phase has been studied. The effect of extraction equilibrium time, influence of different alkyl chains of tartaric acids, types of beta-cyclodextrin derivatives, organic solvents and buffer pH were investigated. It was found that hydroxypropyl- β-cyclodextrin (HP-β-CD) has the strongest recognition ability among three β-CD derivatives of HP-β-CD, hydroxyethyl-β-cyclodextrin (HE-β-CD) and methylated- β-cyclodextrin (Me-β-CD) while D-diisopropyl tartrate has the strongest ability among four tartaric acid derivatives of Ldiisopropyl tartrate, D-diisopropyl tartrate, L-diethyl tartrate and D-diethyl tartrate. The distribution coefficient and enantioselectivity, α gave an optimum value at pH 5.0.

Keywords:

Chiral drug, Enantioselective extraction, Racemic amlodipine.