The Open Conference Proceedings Journal

2011, 2 : 21-27
Published online 2011 April 28. DOI: 10.2174/2210289201102010021
Publisher ID: TOPROCJ-2-2-21

Phase Transitions of Ipidacrine Hydrochloride Polymorphs and Hydrates

A. Dubnika , K. Veldre , A. Actins and J. Lescenko
University of Latvia, Department of Chemistry, Kr.Valdemara Str. 48, Riga, LV-1053, Latvia.

ABSTRACT

Ipidacrine hydrochloride is pharmaceutically active compound that forms variety of crystalline modifications which differs by solvent type and content in crystalline structure. These crystalline forms analyzed by powder x-ray diffraction, differential thermal analysis, thermogravimetry and Karl Fisher titration.

Obtained crystalline forms include two monohydrates, two hemihydrates, two anhydrous forms, two non-stoichiometric hydrates and mixed solvates with octanol and water and methanol and water, solvate with chloroform and dimethylformamide.

Keywords:

Ipidacrine, differential thermal analysis, powder X-ray diffraction.