The Open Conference Proceedings Journal

2013, 4 : 41-41
Published online 2013 March 1. DOI: 10.2174/2210289201304010041
Publisher ID: TOPROCJ-4-4-41

A new Fistularin-3 Derivative from an Australian Sponge Pseudoceratinasp.

Pinus Jumaryatno , Tina Skinner-Adams , Katherine T. Andrews , Rohan A. Davis , Joanne T. Blanchfield and Mary J. Garson
Pharmacy Department, Faculty of Mathematic and Natural Sciences, Universitas Islam Indonesia, Yogyakarta 55584, Indonesia.

ABSTRACT

Chemical investigation of an Australian marine sponge, Pseudoceratina sp., collected from Mooloolaba South-East Queensland has provided a series of bromotyrosine metabolites from a simple modified tyrosine to more elaborate linear compounds. Six known compounds, (+)-aeroplysinin-1 (1), a mixture of 19-deoxyfistularin-3 (2) and 11-deoxyfistularin-3 (3), 11,19- dideoxyfistularin-3 (4), aerothionin (5) and homoaerothionin (6) have been isolated together with a new fistularin-3 derivative, 11-deoxy-19-ketofistularin-3 (7). The structures of all compounds were characterised using 1D and 2D NMR techniques, MS and by comparison with literature data. Two selected fistularin-3 derivative metabolites 4 and 7 were screened for in vitro activity against chloroquine-sensitive (3D7) P. falciparum malaria parasites and showed antimalarial activity with IC50 values of 5.4 and 2.8 μM, respectively.

Keywords:

, bromotyrosine, fistularin-3, antimalarial.