The Open Conference Proceedings Journal

2013, 5 : 21-23
Published online 2013 March 1. DOI: 10.2174/2210289201405020021
Publisher ID: TOPROCJ-5-4-21

Indole Alkaloids from (Apocynaceae)

Mehran Fadaeinasab , A. Hamid A. Hadi , Masoumeh Hoseinzadeh and Hiroshi Morita
Department of Chemistry, Faculty of Science, 50603 University Malaya, Kuala Lumpur.

ABSTRACT

From the methanolic crude extract of Rauvolfia reflexa six indole alkaloids were isolated namely; (1), akuammilan (2), vomilenine (3), isoresrpiline (4), rescinnamine (5), and cantleyine (6). The methanol crude extract showed moderate anticancer activity against MCF-7 and WRL-68 cell lines, although the isolated compounds and dichloromethane crude extract were also tested for anticancer activity but they didn't show significant activity against MCF-7 and WRL-86 cancer cell lines.

Keywords:

Alkaloids, anti cancer activity, Apocynaceae, , NMR..