The Open Conference Proceedings Journal

2014, 5 : 24-26
Published online 2014 June 13. DOI: 10.2174/2210289201405020024
Publisher ID: TOPROCJ-5-4-24

Chemical Constituents Of (Annonaceae)

Ainnul Hamidah Syahadah Azizan and A. Hamid A. Hadi
Department of Chemistry, Faculty of Science, 50603 Kuala Lumpur.

ABSTRACT

Mitrella kentii which belongs to the Annonaceae family is a tree-climbing liana found in the Malaysian Peninsula, Islands of Sumatra, Borneo, and New Guinea. This species was studied in 1972 for their alkaloids, 1997 and 2012 for their non-alkaloid constituents. In this study, chalcones, Desmosdumotin C (1) and their tautomer, 2-cinnamoyl- 3-hydroxy-5-methoxy-4,6,6-trimethylcyclohexa-2,4-dienone (2), flavanone, 7-hydroxy-5,6-dimethoxy-2-phenylchroman- 4-one (3), oxoaporphine alkaloids, Liriodenine (4) and Atherospermidine (5) and also terpenoid, β-Sitostenone (6) have been isolated from this species. All these compounds were isolated for the first time from Mitrella kentii except Liriodenine (4). The isolated compounds were elucidated using spectroscopic techniques such as UV, IR,1D and 2D NMR and mass spectroscopy and by comparison their spectral data with those previously reported in the literatures. Desmosdumotin C (1) showed the anti-ulcer activity.

Keywords:

Annonaceae, Alkaloid, Anti-ulcer activity, Desmosdumotin C, ..