The Open Structural Biology Journal

, 3 : 1-9
Published online . DOI: 10.2174/1874199100903010001
Publisher ID: TOSBJ-3-1

Significance of CH/p Interactions on the Stability of Therapeutic Proteins

K. Ramanathan , V. Shanthi and Rao Sethumadhavan
School of Biotechnology, Chemical and Biomedical Engineering, Bioinformatics Division, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India.

ABSTRACT

A computational analysis on the CH/p interactions in a group of 49 therapeutic proteins was investigated. A total of 77 CH/p interactions were observed. The donor atom contribution to CH/p interactions was mainly from aromatic residues. Long-range CH/p interactions are the predominant type of interactions in therapeutic proteins data set. The secondary structure preference, solvent accessibility and stabilization centers of these of CH/p interacting residues were estimated. 73% of the donor residues and 65% of the acceptor residues were highly conserved.

Keywords:

CH/p interactions, secondary structure, long range interactions, solvent accessibility, stabilization centers, conservation..