The Open Stem Cell Journal

2018, 5 : 47-52
Published online 2018 November 30. DOI: 10.2174/1876893801805010047
Publisher ID: TOSCJ-5-47

REVIEW ARTICLE
 Exploring the Role of Mesenchymal Stem Cells During Normothermic Organ Perfusion: A New Paradigm to Enhance Outcome Following Allograft Transplantation

Mohamed Morsy1, * , Mohammad Ayaz Hossain2 and Atul Bagul3

* Address correspondence to this author at the Consultant Transplant Surgeon, University Hospitals of Leicester/Leicester General Hospital, Leicester, LE5 4PW, UK, E-mail: Mohamed.morsy@nhs.net

ABSTRACT

Background:

Normothermic Machine Perfusion (NMP) has been established in the field of solid organ transplantation for both liver and kidney allografts. The ability to perfuse organs at body temperature enables viability assessment as well as optimisation prior to implantation.

Discussion:

A recent in vitro report of the use of Mesenchymal Stem Cells (MSCs) in the use of a normothermic lung perfusion circuit has raised the possibility of their use in solid organ transplantation. The aim of this short review is to outline the potential uses of bone marrow derived MSCs for their use in renal allograft ex vivo NMP. An overview is provided of current literature of NMP as well as theorised uses for MSCs.

:

Mesenchymal stem cells, Normothermic perfusion, Transplantation, Outcomes, Allograft, EMP.