The Open Spectroscopy Journal

2007, 1 : 9-16
Published online 2007 November 9. DOI: 10.2174/1874383800701010009
Publisher ID: TOSPECJ-1-9

Detection of Gluten Exorphin B4 and B5 in Human Blood by Liquid Chromatography-Mass Spectrometry/Mass Spectrometry

Christopher L. Pennington , Craig P. Dufresne , Giuseppe Fanciulli and Troy D. Wood
Department of Chemistry, University at Buffalo, State University of New York, Buffalo, NY, USA.

ABSTRACT

Liquid chromatography-tandem mass spectrometry was employed to monitor for gluten exorphins (GEs) in blood from samples collected from Celiac Disease subjects after the consumption of a physiological meal. GE-B4 and B5 were detected in three of the four subjects, the first time GEs have been detected in human blood.