The Open Tissue Engineering and Regenerative Medicine Journal

2009, 2 : 40-47
Published online 2009 July 28. DOI: 10.2174/1875043500902010040
Publisher ID: TOTERMJ-2-40

Control Inflammatory Effect in Tissue Engineering with Chitosan Nanoparticles, Influence of Sterilization Process

Larena A. , Cáceres D.A. and Ramos-Ortiz G.
Department of Chemical Industrial Engineering and Environment, ETS de Ingenieros Industriales, Universidad Politécnica de Madrid, José Gutiérrez Abascal, 2 – 28006 Madrid, Spain.

ABSTRACT

Tissue engineering and regenerative medicine are disciplines in constant evolution to provide solutions, to assist and accelerate the regeneration and repairing of defective and damaged tissues. Many repair techniques produce inflammatory effects that difficult the regenerative process. In the present work we present a summary of our experience in using chitosan formulations as cells carrier for bone and cartilage regeneration. We have found that the use of chitosan lead to inflammatory processes in tissular repairing. To overcome this we proposed the introduction of anti-inflammatory products during the tissular regeneration and here we describe the experimental results on the control inflammatory effect in tissue engineering with chitosan nanoparticles under different sterilization process. It was found that chitosan nanoparticles have potential applications for several therapeutical drugs administration.

Keywords:

Chitosan nanoparticles, inflammatory effect, tissue engineering.