The Open Tropical Medicine Journal

2009, 2 : 17-23
Published online 2009 April 24. DOI: 10.2174/1874315300902010017
Publisher ID: TOTMJ-2-17

Correlation of Plasma Soluble Fas Ligand Levels with Severe Anaemia in Gabonese and Indian Plasmodium falciparum Malaria Patients

Vincent Guiyedi , Prakash Deshpande , Constantin Fesel , Rajendra Jain , Arnaud Dzeing-Ella , Pierre-André Cazenave , Maryvonne Kombila , Gyan Chandra Mishra and Sylviane Pied
Unité INSERM U547, Institut Pasteur de Lille, 1 rue du Pr A. Calmette, 59019 Lille, France.

ABSTRACT

A comparative analysis of the plasma concentrations of soluble Fas-L (sFas-L) and their correlation with hemoglobin levels and malaria severity was carried out in cohorts of P. falciparum-infected patients from Gabon and India. Young patients from Gabon had plasma levels of sFas-L that increased with disease severity. In contrast, in Indian adults plasmatic sFas-L levels were more elevated in UM and SNCM than in CM. In both Gabonese and Indian subjects, sFas-L concentrations were negatively correlated with haemoglobin rates, which were lower in SNCM than in UM or CM in both populations. We also observed a positive correlation between the level of plasmatic sFas-L with the level of circulating IL-2 receptor in the Indian patients. All these observations suggest a paradoxical role of sFas-L in CM pathogenesis when comparing Gabonese and Indian patients, while a similar role was found to be associated with severe anaemia.

Keywords:

sFasL, P. falciparum, severe malaria.