The Open Tropical Medicine Journal

2009, 2 : 8-12
Published online 2009 February 27. DOI: 10.2174/1874315300902010008
Publisher ID: TOTMJ-2-8

Low Efficacy of Vocamine (MMH8, Pediatric Formulation) in the Treatment of Uncomplicated Plasmodium falciparum Malaria

Didier Ménard , Nestor Madji , Alexandre Manirakiza , Alain Le Faou and Gérard Grésenguet
Unité du Paludisme – Malaria Unit, Institut Pasteur de Madagascar, BP 1274 - Antananarivo 101, Madagascar.

ABSTRACT

Background: This paper reports for the first time, the antimalarial efficacy of a five-day course of paediatric formulation of “vocamine” named MMH8® from Millenia Hope Inc® for the treatment of uncomplicated Plasmodium falciparum malaria.

Methods: We used the standard 14-day WHO protocol to assess therapeutic responses in children less than 5 years in Bangui (Central African Republic) between January and March 2005.

Results: We observed high rate of failure treatment: 81 % overall treatment failure with 51 % of Early Treatment Failure and 28.6 % of Late Treatment Failure.

Conclusion: Convinced that this drug has only a limited antimalarial effect, the Ministry of Health of the Central African Republic has decided to stop this clinical trial.