Sub-Chronic Toxicity Study of Fixed Dose Combination of Ofloxacin- Ornidazole in Mus Musculus Mice

ABSTRACT

The present study investigated safety/toxicity profile of fixed dose combination of Ofloxacin-Ornidazole injection in Mus musculus mice at three dose levels, ranging from asymptomatic to high dose. To enhance the antimicrobial spectrum of the quinolones against anaerobic organisms and gram positive bacteria, fixed dose combination of Ofloxacin and Ornidazole injection was introduced. It has been found highly effective as well as synergistic and has the potential of usage for empirical therapy because of extended spectrum. A 30 days repeat dose subchronic toxicity study was conducted on mice (male and female). Various physiological, hematological and biochemical parameters were studied. There were no signs of toxicity observed at any dose level used in this study. No mortality was seen in any of the treatment groups. Hematological as well as physiological parameters were unaltered at three dose levels in Ofloxacin-Ornidazole treatment groups. Results suggest that the fixed dose combination of Ofloxacin-Ornidazole injection is non toxic even at maximum dose level.

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