The Open Toxicology Journal

2013, 6 : 20-26
Published online 2013 May 30. DOI: 10.2174/1874340401306010020
Publisher ID: TOTOXIJ-6-20

A Practical Guide to the Calculation of Uncertainty of Measurement

Mario Zilli
ARPA F.V.G., Settore Laboratorio Unico, Laboratorio di Gorizia, Italy

ABSTRACT

This paper would provide the analyst with an easy to use step-by-step guide to calculate the uncertainty of measurement in implementing a new analytical method. There are two main ways to attain such an achievement. The first is to consider all the possible sources of variability and then to sum up all of them in the final calculation. The second is taking part in a collaborative trial and processing the resulting statistics. Both methods imply different advantages and drawbacks. It is up the analyst to choose the one fits best his requirements. Anyway it is nearly inescapable providing, along with the test result, its own uncertainty.