The Open Transplantation Journal

2008, 2 : 29-34
Published online 2008 August 7. DOI: 10.2174/1874418400802010029
Publisher ID: TOTRANSJ-2-29

A Possible Interaction of Voriconazole and Warfarin in a Renal Transplant Recipient

A. Scott Mathis and Daryl S. Schiller
Department of Pharmacy, Saint Barnabas Medical Center, Livingston, New Jersey, USA.

ABSTRACT

A potential warfarin – voriconazole interaction has been identified in one study involving healthy individuals. We report a case where addition of voriconazole possibly increased the international normalized ratio (INR) in a renal transplant patient taking warfarin. The INR elevation was resistant to reversal agents, and the situation may have ultimately contributed to a thrombotic episode.