The Open Transplantation Journal

2008, 2 : 62-65
Published online 2008 October 30. DOI: 10.2174/1874418400802010062
Publisher ID: TOTRANSJ-2-62

Post Transplantation Lymphoproliferative Disorder (PTLD) Presenting as Biliary Duct Obstruction

Isabelle Morard , Gilles Mentha , Laura Rubbia , Sylvain Terraz , Laurent Spahr , Antoine Hadengue , Pietro Majno , Philippe Morel and Emiliano Giostra
Hepatogastroenterology, Hôpitaux Universitaires de Genève, Geneva, Switzerland.

ABSTRACT

After adult liver transplantation (LT), post-transplant lymphoproliferative disorder (PTLD) is an uncommon but serious complication of immunosuppression (IMS) in presence of an acute or latent EBV infection. The clinical presentation of this disease is aspecific, and, after LT, it may mimic anastomotic bile duct stricture. We report the cases of 2 adult patients who developed, 3 months and 8 years after OLT, an EBV-associated PTLD with diffuse intrinsic infiltration of bile duct mimicking anastomotic biliary stricture. In the absence of liver or hilar nodes involvement, percutaneous biopsies were non contributive and the diagnosis were made by surgical biopsy. After reduction of IMS and Rituximab treatment, both patients are alive without recurrence 5 and 6 years after diagnosis. In conclusion, PTLD is one of the differential diagnosis of biliary tree obstruction after OLT. Diagnosis requires surgical biopsies and treatment consists in IMS reduction and Rituximab.