The Open Virology Journal

2017, 11 : 15-27
Published online 2017 March 31. DOI: 10.2174/1874357901711010015
Publisher ID: TOVJ-11-15

REVIEW ARTICLE
 Cytomegalovirus, Macrophages and Breast Cancer

S. Pasquereau1 , F. Al Moussawi1 , W. Karam2 , M. Diab Assaf2 , A. Kumar1 and G. Herbein1, *

* Address correspondence to this author at the Pathogens & Inflammation Laboratory, Department of Virology, University of Franche-Comté, CHRU Besançon, 16 Route de Gray CS11809, F-25030 Besançon cedex, France; Tel: +33 626 479 529; Fax: + 33 381 665 695; E-mail: georges.herbein@univ-fcomte.fr

ABSTRACT

The human cytomegalovirus (HCMV) is a betaherpesvirus that is highly host specific, infects among others epithelial cells and macrophages, and has been recently mentioned as having oncomodulatory properties. HCMV is detected in the breast tumor tissue where macrophages, especially tumor associated macrophages, are associated with a poor prognosis. In this review, we will discuss the potential implication of HCMV in breast cancer with emphasis on the role played by macrophages.

Keywords:

HCMV, Tumor, Macrophages, Breast cancer.