The Open Virology Journal

2008, 2 : 37-43
Published online 2008 April 25. DOI: 10.2174/1874357900802010037
Publisher ID: TOVJ-2-37

RESEARCH ARTICLE
 Formulation of New Algorithmics for miRNAs

Yoichi Robertus Fujii, *
Nagoya City University, Nagoya, 467-8603, Japan

* Address correspondence to this author at the Nagoya City University, Nagoya, 467-8603, Japan; E-mail: yofuji@phar.nagoya-cu.ac.jp

ABSTRACT

microRNAs (miRNAs) are a class of small RNAs, 21-25 nucleotides (nts) long with single-stranded RNA. miRNA targets the sequences of messenger RNA (mRNA) through incomplete base-pairing of the target sequence. The incomplete pairing of miRNA to mRNA triggers either translational repression or epigenetically mediated transcriptional gene silencing (TGS). miRNA and RNA silencing in mammalian cells may participate in natural ecological interactions and miRNA itself should contain the original information that is required to control viral proliferation, according to the hypothesis of RNA waves. While the hypothesis involves so-called resident and genomic miRNA as the genetic information, resident miRNAs may evolve and jump into other RNAs, and then become genomic miRNAs. Thus, the inheritable character may be acquired by both types of miRNAs. It is reasonable to believe that preparations of new algorithmics models for the flow of miRNAs may provide an opportunity to overcome the acquired immunodeficiency syndrome (AIDS) pandemic.

Keywords:

AIDS, HIV, microRNA, nef, non-coding RNA, retrotransposon, RNA interference..