The Open Veterinary Science Journal

2007, 1 : 11-13
Published online 2007 December 30. DOI: 10.2174/1874318807001010011
Publisher ID: TOVSJ-1-11

Evaluation of a Murine Model for Intranasal and Intraperitoneal Infection by Haemophilus parasuis: Short Report

Ana-Judith Martín de la Fuente , César-B. Gutiérrez Martín , Sonia Martínez Martínez , Rafael Frandoloso and Elías-F. Rodríguez Ferri
Department of Animal Health, Section of Microbiology and Immunology, Faculty of Veterinary Medicine, University of León, 24007-León, Spain.

ABSTRACT

NMRI mice were evaluated as model for experimental infection by Haemophilus parasuis by intranasal (IN) and intraperitoneal (IP) routes. No deaths, clinical signs and macroscopic lesions were noticed after receiving several doses (except when the mice were infected intraperitoneally with the highest dose), and the organism was cleared rapidly from spleen and lungs. These results suggest that NMRI mice are not a suitable model to reproduce experimentally Glässer’s disease.

Keywords:

Haemophilus parasuis, Glässer’s disease, mouse.