Serum Taurine as a Marker of Endometrial Cancer

ABSTRACT

Serum taurine levels were measured in fifty women selected from a wide number of patients presented with irregular uterine bleeding (IUB) to the outpatient clinic of the Obstetrics and Gynecology Hospital, Ain Shams University. No significant differences in age and menopausal status were found. The control group comprised ten healthy women that enrolled as volunteers. According to the findings observed after full clinical examination, ultrasonography, endometrial biopsy or fractional uterine curetting and tumor marker (CA-125) determination, 15 women were diagnosed with endometrial cancer (EC), 10 with cystic endometrial hyperplasia (CEH), 15 with fibromyoma, and 10 women were diagnosed as dysfunctional uterine bleeding (DUB). The results showed non significant (P > 0.05) changes in the levels of CA-125 in all patients except in the cancer group where it exhibited a value nearly double that of normal (P < 0.01). Serum taurine levels exhibited values lower than control with 8 %, 14 % , 32 % and 56 % in the serum of patients diagnosed as DUB (P > 0.05), fibromyoma (P > 0.05), CEH (P < 0.01) and EC (P < 0.01) respectively . In conclusion, the data suggests that measurement of serum taurine in women with irregular uterine bleeding could help the early detection of malignant transformation of endometrial wall. .

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