The Utility of Vascular Dysfunction Studies in the Prediction and Prevention of Preeclampsia: A Historical Review

ABSTRACT

Preeclampsia is a major cause of maternal and perinatal mortality. Although preeclampsia may be caused by several factors, endothelial cell dysfunction has been proposed as the main pathophysiological cause. Dysfunctional endothelium in the uteroplacental circulation not only increases peripheral vascular resistance, but also affects generalized vasoconstriction via humoral factors released from the placenta. A standard method for predicting and preventing preeclampsia has yet to be developed; however, the analysis of a combination of biochemical markers, particularly markers related to vascular dysfunction, may enhance our ability to predict and prevent preeclampsia in the near future.

Keywords:

Angiogenic growth factor, endothelial cell activation, inflammatory response, oxidative stress, preeclampsia.