Lipoprotein (a) and Stroke: An Overview

ABSTRACT

Stroke remains a major cause of mortality and long term severe disability worldwide. Lipoprotein (a) [Lp(a)] is a predictor of many forms of vascular disease, and may serve as a tool in identifying subjects at risk. Despite accumulating evidence from cross sectional and prospective studies, its role in the development of stroke is still in doubt. Methodological issues regarding measurement remain to be resolved. Whether reductions in Lp(a) levels will result in a reduction of vascular events, including stroke, remains to be established. Aggressive management of established cardiovascular risk factors is advocated in subjects exhibiting elevated serum Lp(a) concentrations.