The Open Infectious Diseases Journal

2022, 14 : e187427932211280
Published online 2022 December 30. DOI: 10.2174/18742793-v14-e221129-2022-5
Publisher ID: e187427932211280

RESEARCH ARTICLE
 Impact of Pregnancy on the Prognosis of COVID-19 in Women Hospitalized at the National Reference Center for Patients Infected with SARS-CoV-2 in a Resource-limited Country

Awèréou Kotosso1,2, * , Baguilane Douaguibe1,3 , Lidaw D. Bawe1,2 , Akouda A. Patassi1,4 , Sarakawabalo Assenouwe2,5 , Koffi A. Aziagbe1,2 , Yaovi M. Tsevi1,2 , Bawoubadi Abaltou2 , Sesso Zouwera2 , Gani Watara2 , Laroutoki Macamanzi2 , Komi S. Adjoh1,6 , Majesté I. Wateba1,4 and Awalou M. Djibril1,7,8

*Address correspondence to this author at the Faculty of Health Sciences, University of Lomé, Togo and Lomé commune Regional Hospital Center, Lomé, Togo; Tel: +228 90 17 38 09; E-mail: kotosso02@yahoo.fr

ABSTRACT

Aim:

The aim of the study was to reduce morbidity and mortality associated with COVID-19 in pregnant women.

Background:

Since the detection of the first case of COVID-19 on March 6, 2020, in Togo, pregnant women have received special attention due to their usual vulnerability to infection.

Objective:

The objective of this study was to evaluate the influence of pregnancy on the prognosis of COVID-19 in patients hospitalized in Lomé.

Methods:

This was an analytical cross-sectional study of women of childbearing age (15-49 years) admitted between March 22, 2020, and December 31, 2021, to the Lomé Commune Regional Hospital, a national referral center for COVID-19 patients.

Results:

We registered 438 women of childbearing age, including 31 pregnant women (7.1%). Pregnant women were younger (28.8 years vs. 34.2 years, p = 0.001). Asthenia was more common in pregnant women (38.7% vs. 20.6%, p = 0.025), and SpO2 was lower (88.6% vs. 94%, p= 0.016%). Pregnancy was not associated with the occurrence of severe forms nor with prolonged hospitalization. Independent risk factors for mortality were 3rd trimester of pregnancy, mean age > 34 years, diabetes, HIV, and obesity.

Conclusion:

Most symptoms were similar to those observed in the general population. However, in addition to comorbidities, complications in the third trimester of pregnancy have worsened the prognosis for COVID-19. These results corroborate the observations made in the subregion. However, it is important to assess the effect of COVID-19 on pregnancy outcomes.

Keywords:

COVID-19, Pregnancy, Prognosis, SARS-CoV-2, Mortality, Patients.