The Open Infectious Diseases Journal

2008, 2 : 8-13
Published online 2008 May 8. DOI: 10.2174/1874279300802010008
Publisher ID: TOIDJ-2-8

RESEARCH ARTICLE
 No Long-Term Risk for Increased Spread of PNSP in Day-Care Centres by Permitting Carriers to Remain in the Day-Care Centre Group

B. Christenson1, * , B. Henriques Normark2 , B. Ardung1 , K. Sjöström2 , G. Eriksson1 , P. Hartvig3 and S.P.E. Sylvan1, *
1 Department of Communicable Disease Control and Prevention, Uppsala County Council, Uppsala, Sweden
2 Swedish Institute for Infectious Disease Control, Solna, Sweden
3 Department of Hospital pharmacy, Akademiska Hospital, University of Uppsala, Sweden

* Address correspondence to this author at the Department of Communicable Disease Control and Prevention, Uppsala County Council, Dag Hammarskjolds vag 17, SE-751 85 Uppsala, Sweden.Email: staffan.sylvan@lul.se

ABSTRACT

In a 6-year prospective epidemiological intervention study the spread of pneumococci non-susceptible to penicillin (PNSP) was studied among children attending day-care centres (DCCs). A primary aim was to investigate whether there was a risk for spread of PNSP by permitting children carrying PNSP strains to remain in the DCC. Carriers were followed until they presented negative cultures. The PNSP strains were characterised by serotyping, antibiotic susceptibility testing and clonality. Thirteen children with PNSP, initiated sampling of 321 children, 66 DCC personnel and 149 family members. Twenty-three (7 %) asymptomatic carriers were identified but none among the personnel. The most spread serotype was 6B (47%), followed by 19F (17%) and 9V (14%). The PNSP isolates were resistant to three antibiotics or more (69%). The spreading capability and duration of carriage differed between PNSP clones but no long-term risk for increased spread of PNSP in DCCs by carriers was found.