The Open Infectious Diseases Journal

2009, 3 : 143-147
Published online 2009 December 24. DOI: 10.2174/1874279301004010143
Publisher ID: TOIDJ-3-143

RESEARCH ARTICLE
 Syphilis: A Review of the Diagnosis and Treatment

Carol R. Emerson, *
Genitourinary and HIV Medicine, Royal Group Hospitals, Belfast, UK.

* Address correspondence to this author at the Genitourinary and HIV Medicine, Royal Group Hospitals, Belfast, UK.Tel: +442890634559; Fax: +442890322303; E-mail: carolemerson15@hotmail.com

ABSTRACT

Syphilis has re-emerged as an important cause of morbidity, mortality and a possible transmission factor in the spread of HIV infection. The control of syphilis requires early identification and treatment of cases. Here the diagnostic tests are reviewed and discussed, including when to think of lumbar puncture for the examination of neurosyphilis. The British, European and American guidelines for treatment at each stage are compared; with efficacy and side effect profile of regimens considered and advice on management of complications. Stemming the spread of infection requires increased education, early diagnosis and prompt notification of partners.