The Open Nuclear Medicine Journal

2011, 3 : 10-11
Published online 2011 July 6. DOI: 10.2174/1876388X01103010010
Publisher ID: TONMEDJ-3-10

Human Subject with Unexpected Biodistribution of [C]PK11195

Anne Roivainen , Kjell Någren , Jere Virta and Juha Rinne
Turku PET Centre, Turku University Hospital, FI-20521 Turku, Finland

ABSTRACT

[N-Methyl-11C](R)-1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinoline carboxamide [11C]PK11195 is a widely used radiopharmaceutical for in vivo assessment of translocator protein 18 kDa (TSPO) activity using positron emission tomography. Here we present an interesting case of unusual distribution of [11C]PK11195, that is a lack of uptake in tissues known for high expression of the TSPO.