The Open Nuclear Medicine Journal

2012, 4 : 1-4
Published online 2012 March 9. DOI: 10.2174/1876388X01204010001
Publisher ID: TONMEDJ-4-1

Gallium-67 Uptake in Histological Variants of Non-Hodgkin’s Lymphoma – A Correlative Study

Basit Iqbal , Geoffrey M Currie , Humayun Bashir , Uzma Afzal , M. Khalid Nawaz , Samina Mansoor , Janelle M Wheat and Muhammad Numair Younis
Pakistan Institute of Engineering & Applied Sciences, Islamabad, Pakistan.

ABSTRACT

Introduction:

The malignant lymphomas are the fifth most common neoplasm in both men and women. Staging, re-staging and treatment response evaluation pose a difficult task in many patients of lymphomas. Histological variants in both Hodgkin's and Non-Hodgkin's types of lymphoma greatly affect the response to treatment and overall prognosis.

Objective:

This study was conducted to correlate the degree of abnormal Gallium-67 uptake with the histological variants of non-Hodgkin's lymphoma. This project was a part of the study to see the ability of Gallium-67 scintigraphy to predict the response to chemotherapy early in the course of therapy.

Material & Methods:

65 patients were included in the study with a mean age of 25 years. All patients had undergone medical imaging, bone marrow biopsy and histopathology.

Results:

Sixty-five patients were classified according to the REAL classification. 11 patients were of T-cell type, 50 were of B-cell type and 4 were anaplastic. 46 showed gallium-67 uptake in the lesions, whereas 19 (29.2%) had no discernable Gallium-67 uptake.

Conclusion:

There was no correlation between histological sub-types and Gallium-67 uptake in all sub-types of NHL.