The Open Pharmacology Journal
2018, 8 : 21-28Published online 2018 October 30. DOI: 10.2174/1874143601808010021
Publisher ID: TOPHARMJ-8-21
RESEARCH ARTICLE
Polysorbate 80 Coated Solid Lipid Nanoparticles for the Delivery of Temozolomide Into the Brain
* Address correspondence to this author at the Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India; Mobile: 9888206383; E-mails: ; amitkumargoyal1979@gmail.com
ABSTRACT
Introduction:
Anti-angiogenic therapy can produce transient regression in tumor in case of Glioblastoma (GBM); however, no prolongation of patient survival rate had so far been achieved.
Methodology:
To address this problem, an effort was made to design and characterize a temozolomide loaded nanosystem for targeting the tumor vasculature in the brain using polymeric nanoparticles. It included the formation of Temozolomide (TMZ) loaded Solid-Lipid Nanoparticles (SLNs) and their conjugation with polysorbate-80 (P-80) which enhanced the penetration of drug to blood-brain barrier resulting in the enhancement of pro-apoptotic activity.
Results:
Conjugating nanoparticles with a tumor-penetrating polymer (P-80) further enhanced the therapeutic efficacy of the drug.
Conclusion:
The animal studies indicated the enhanced potential of the developed system in the effective treatment of glioblastoma.